首页 | 【重要提示】 | 期刊简介 | 编委会 | 在线投稿 | 期刊稿约 | 联系我们

蔡毅,郑明辉,王翔,任涛,冯仕烽,瞿东滨.术前血清C反应蛋白水平与胸腰骶椎结核术后未愈的关系[J].脊柱外科杂志,2018,16(4):195-199.
术前血清C反应蛋白水平与胸腰骶椎结核术后未愈的关系     点此下载全文 (Fulltext)
蔡毅  郑明辉  王翔  任涛  冯仕烽  瞿东滨
南方医科大学南方医院脊柱骨科, 广东 510515
基金项目:国家自然科学基金(81272022)
DOI:10.3969/j.issn.1672-2957.2018.04.002
摘要点击次数: 68
全文下载次数: 40
摘要:
      目的 探讨术前血清C反应蛋白(CRP)水平与胸腰骶椎结核术后未愈的关系。方法 回顾性分析2007年1月-2015年12月行一期病灶清除、椎间植骨融合内固定术治疗的123例胸腰骶椎结核患者的临床资料。根据术前CRP中位数(17.7 mg/L)将患者分为CRP > 20 mg/L组(A组,n=57)和CRP ≤ 20 mg/L组(B组,n=66),比较2组在年龄、性别、病程、术前合并症、术前抗结核治疗时间、术前白蛋白、病变部位、病变范围、手术入路等一般临床特征上的均衡性。观察术后1年随访期内结核病灶未愈情况,采用Cochran-Mantel-Haenszel(CMH)检验控制混杂因素并分析2组间未愈率的差异。结果 2组间性别、术前白蛋白存在不均衡,而年龄、病程、术前合并症、术前抗结核治疗时间、病变部位、病变范围、手术入路等特征差异无统计学意义。共12例(9.8%)患者术后未愈,A组和B组的未愈率分别为15.8%(9/57)和4.5%(3/66)。控制性别和术前白蛋白的影响后,得到A组未愈率高于B组,差异有统计学意义(P<0.05)。结论 较高的术前CRP水平可能增加胸腰骶椎结核术后未愈风险,应重视手术时机选择,并在术前有效控制结核炎症。
关键词:胸椎  腰椎  骶骨  结核,脊柱  C反应蛋白质  伤口愈合
Relationship between preoperative serum C-reactive protein and postoperative non-healing in thoraco-lumbo-sacral vertebral tuberculosis patients    Fulltext
CAI Yi  ZHENG Ming-hui  WANG Xiang  REN Tao  FENG Shi-feng  QU Dong-bin
Department of Spinal Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Fund Project:
Abstract:
      Objective To explore the relationship between preoperative serum C-reactive protein(CRP) with postoperative non-healing in thoraco-lumbo-sacral vertebral tuberculosis patients. Methods All 123 thoraco-lumbo-sacral vertebral tuberculosis patients who were treated by one-stage debridement,bone graft fusion and internal fixation between January 2007 and December 2015 were retrospectively analyzed.According to the median preoperative CRP(17.7 mg/L),the patients were divided into group A(with CRP > 20 mg/L,n=57) and group B(with CRP ≤ 20 mg/L,n=66). The general characteristics were compared between 2 groups,including age,gender,course of disease,preoperative comorbidities,duration of preoperative anti-TB treatment,preoperative albumin,location and extent of spinal lesion and surgical approach. Postoperative non-healing was collected during 1-year follow-up period. Cochran-Mantel-Haenszel tests were conducted to control the confounding factors and analyze the differences in postoperative non-healing rate between 2 groups. Results Postoperative non-healing was observed in 12 cases(9.8%). There were differences in gender and preoperative albumin between 2 groups. While there was no difference in age,course of disease,preoperative comorbidities,duration of preoperative anti-TB treatment,location and extent of spinal lesion and surgical approach. The postoperative non-healing rates of groups A and B were 15.8%(9/57) and 4.5%(3/66),respectively. After controlling for gender and preoperative albumin,the non-healing rate of group A was significantly higher than that of group B(P<0.05). Conclusion A higher level of preoperative CRP might increase the risk of postoperative non-healing in thoraco-lumbo-sacral vertebral tuberculosis patients,therefore suitable surgical timing and effective management of preoperative inflammation in these patients should be emphasized.
Keywords:Thoracic vertebrae  Lumbar vertebrae  Sacrum  Tuberculosis,spinal  C-reactive protein  Wound healing
HTML   在线阅读   查看全文  查看/发表评论  下载PDF阅读器

您是第1337238位访问者

版权所有 © 脊柱外科杂志    沪ICP备07510177号-8

地址:上海市成都北路500号峻岭广场 电子信箱:spinejournal@163.com
邮政编码:200003 电话:021-33300675,021-63609919转8537或8855 传真:

本系统由北京勤云科技发展有限公司设计