| 陈莹,盛珺,刘达,郑伟,伍红桦,李剑,周江军.唑来膦酸改善骨质疏松患者后路腰椎椎间融合术后腰痛[J].脊柱外科杂志,2019,17(5):319-323. |
唑来膦酸改善骨质疏松患者后路腰椎椎间融合术后腰痛  点此下载全文 (Fulltext) |
| 陈莹1 盛珺1 刘达1* 郑伟1 伍红桦1 李剑1 周江军2 |
1. 中国人民解放军西部战区总医院骨科, 成都 610083;
2. 中国人民解放军联勤保障部队第908医院骨科, 鹰潭 335000 |
| 基金项目：国家自然科学基金青年科学基金项目（81301606）；四川省卫生和计划生育委员会科研课题（16PJ020）；四川省科技计划项目重点研发项目（2017SZ0116）；四川省干部保健科研课题（川干研2017-1301） |
| DOI：10.3969/j.issn.1672-2957.2019.05.005 |
| 摘要点击次数: 773 |
| 全文下载次数: 358 |
| 摘要： |
| 目的 了解唑来膦酸对骨质疏松患者行后路腰椎椎间融合术（PLIF）后腰痛的影响，评价唑来膦酸的安全性与有效性。方法 选取2013年6月-2015年6月在中国人民解放军西部战区总医院因腰椎退行性疾病接受PLIF治疗的63例骨质疏松症患者，按照随机数字表法分为对照组和治疗组，术后均给予相同的抗骨质疏松基础治疗（口服碳酸钙D3片），治疗组联合应用唑来膦酸治疗。记录并比较2组患者术前及术后随访期疼痛视觉模拟量表（VAS）评分及Oswestry功能障碍指数（ODI）。结果 术前及术后1周，2组腰痛VAS评分无显著差异；术后各时间点2组腰痛VAS评分较术前均明显下降，差异有统计学意义（P<0.05）；治疗组术后1、3、6和12个月的腰痛VAS评分低于对照组，差异有统计学意义（P<0.05）。术前2组ODI无明显差异；术后各时间点2组ODI均较术前明显改善，且治疗组优于对照组，差异均有统计学意义（P<0.05）。结论 骨质疏松患者PLIF后应用唑来膦酸，有助于减轻患者术后中远期腰痛，改善患者术后腰椎功能。 |
| 关键词：腰椎 骨质疏松 脊柱融合术 手术后并发症 二膦酸盐类 |
| Zoledronic acid improving low back pain in osteoporotic patients after posterior lumbar interbody fusion Fulltext |
| CHEN Ying1 SHENG Jun1 LIU Da1* ZHENG Wei1 WU Hong-hua1 LI Jian1 ZHOU Jiang-jun2 |
1. Department of Orthopaedics, General Hospital of Western Theater Command of Chinese PLA, Chengdu 610083, Sichuan, China;
2. Department of Orthopaedics, 908 Hospital of Joint Logistics Support Force of Chinese PLA, Yingtan 335000, Jiangxi, China |
| Fund Project: |
| Abstract: |
| Objective To evaluate the effectiveness and safety of zoledronic acid on low back pain in osteoporotic patients after posterior lumbar interbody fusion (PLIF). Methods From June 2013 to June 2015, 63 patients with osteoporosis who underwent PLIF for degenerative lumbar diseases in the General Hospital of Western Theater Command of Chinese PLA were divided into control group and treatment group according to random number table. The same anti-osteoporosis basic treatmen(t oral calcium carbonate D3 tablets) was given in both groups after surgery, and the treatment group was treated with an intravenous infusion of zoledronic acid. The pain visual analogue scale (VAS) score and Oswestry disability index (ODI) were recorded and compared between the 2 groups before and during the follow-up period. Results There was no significant difference in VAS score between the 2 groups before and 1 week after operation. The VAS scores of the 2 groups were significantly decreased after operation. At each time point of post-operation, the VAS scores were significantly lower in the treatment group than in the control group, with a statistical significance (P<0.05). There was no significant difference in ODI between the 2 groups before operation. The ODI of the 2 groups were significantly improved after operation, and the treatment group was superior to the control group, with a statistical significance (P<0.05). Conclusion The application of zoledronic acid after PLIF in osteoporotic patients can help to alleviate the long-term lumbar pain and improve the function of the lumbar spine. |
| Keywords:Lumbar vertebrae Osteoporosis Spinal fusion Postoperative complications Diphosphonates |
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