| 王亮,徐美玲,韩霖,卢旭华,蒋永丰.经皮椎体成形术中注入不同剂量骨水泥治疗老年骨质疏松性单椎体压缩性骨折[J].脊柱外科杂志,2020,18(5):289-292,314. |
经皮椎体成形术中注入不同剂量骨水泥治疗老年骨质疏松性单椎体压缩性骨折  点此下载全文 (Fulltext) |
| 王亮1△ 徐美玲1△ 韩霖1 卢旭华1* 蒋永丰2* |
1. 海军军医大学附属长征医院骨科, 上海 200003;
2. 解放军第947医院骨科, 喀什 844200 |
| 基金项目：国家自然科学基金面上项目（81572201）；上海市卫生与计划生育委员会科研课题重点项目（201540379）；上海申康医院发展中心临床科技创新项目（SHDC12016214） |
| DOI：10.3969/j.issn.1672-2957.2020.05.001 |
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| 摘要： |
| 目的 探讨经皮椎体成形术（PVP）中注入不同剂量骨水泥治疗骨质疏松性椎体压缩性骨折（OVCF）的临床应用效果。方法 回顾性分析2017年7月—2018年7月在海军军医大学附属长征医院接受PVP治疗的122例老年胸腰椎单椎体OVCF患者临床资料。51例患者术中注入小剂量骨水泥（小剂量组，≥2.5 mL且< 4.0 mL），71例患者术中注入大剂量骨水泥（大剂量组，≥4.0 mL且< 6.0 mL）。记录2组患者手术前后疼痛视觉模拟量表（VAS）评分、椎体前缘高度及术后骨水泥渗漏率。结果 2组患者术后1个月、1年的VAS评分均较术前明显改善，差异有统计学意义（P < 0.05），术后各时间点组间比较差异无统计学意义（P > 0.05）。2组患者术后伤椎前缘高度均较术前显著改善，且大剂量组改善程度优于小剂量组，差异均有统计学意义（P < 0.05）。大剂量组骨水泥总渗漏率为14.08%（10/71），小剂量组骨水泥总渗漏率为5.88%（3/51），组间比较差异无统计学意义（P > 0.05）。结论 PVP术中注入不同剂量骨水泥治疗老年单椎体OVCF均可获得良好的临床效果，改善患者临床症状，恢复脊柱功能，且注入大剂量骨水泥可更有效地恢复椎体高度。 |
| 关键词：胸椎 腰椎 骨折,压缩性 骨质疏松 椎体成形术 骨代用品 手术中并发症 |
| Percutaneous vertebroplasty with different doses of bone cement for single segment osteoporotic vertebral compression fractures in elderly Fulltext |
| WANG Liang1△ XU Mei-ling1△ HAN Lin1 LU Xu-hua1* JIANG Yong-feng2* |
1. Department of Orthopaedics, Changzheng Hospital, Navy Medical University, Shanghai 200003, China;
2. Department of Orthopaedics, No. 947 Hospital of Chinese PLA, Kashi 844200, Xinjiang Uyghur Autonomous Region, China |
| Fund Project: |
| Abstract: |
| Objective To investigate the clinical efficacy of percutaneous vertebroplasty（PVP） for osteoporotic vertebral compression fracture（OVCF） with different doses of bone cement. Methods The clinical data of 122 elderly patients with single-segment OVCF treated by PVP in Changzheng Hospital，Affiliated to Navy Medical University from July 2017 to July 2018 were retrospectively analyzed. Fifty-one patients were injected with low-dose bone cement（low-dose group，≥2.5 mL and < 4.0 mL），and 71 with high-dose bone cement（high-dose group，≥4.0 mL and < 6.0 mL）. The visual analogue scale（VAS） score and anterior height of injured vertebra at pre- and post-operation，and leakage rate of bone cement were recorded. Results The VAS score in the 2 groups were significantly improved at postoperative 1 month and 1 year，and the differences were statistically significant（P < 0.05）；there was no significant difference between the 2 groups at each time point post-operation（P > 0.05）. The anterior height of injured vertebra in the 2 groups was significantly improved at post-operation，and the improvement in the high dose group was better than that in the low-dose group，all with a statistical significance（P < 0.05）. The leakage rate of bone cement was 14.1%（10/71） in the high-dose group，and 5.9%（3/51） in the low-dose group，without a statistical significance（P > 0.05）. Conclusion PVP in the treatment of single-segment OVCF with different doses of bone cement can achieve good clinical efficacy，improve the clinical symptoms of patients，restore the function of the spine，and high doses of bone cement can more effectively restore the height of the vertebral body. |
| Keywords:Thoracic vertebrae Lumbar vertebrae Fractures,compression Osteoporosis Vertebroplasty Bone substitutes Intraoperative complications |
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