| 王茂蓉,彭娜*.强直性脊柱炎患者生活质量的影响因素分析[J].脊柱外科杂志,2020,18(5):331-334. |
强直性脊柱炎患者生活质量的影响因素分析  点此下载全文 (Fulltext) |
| 王茂蓉 彭娜* |
| 华中科技大学同济医学院附属协和医院骨科, 武汉 430022 |
| 基金项目： |
| DOI：10.3969/j.issn.1672-2957.2020.05.009 |
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| 摘要： |
| 目的 探讨影响强直性脊柱炎（AS）患者生活质量的相关因素。方法 选取2017—2019年在本院治疗的AS患者为研究对象。采集患者空腹静脉血，检测人类白细胞抗原B27（HLA-B27）、C反应蛋白（CRP）、红细胞沉降率（ESR）。采用AS疾病活动评分-CRP指标（ASDAS-CRP）评估患者疾病活动情况，改良Stoke AS脊柱评分系统（mSASSS）评估脊柱病变情况，AS生活质量问卷（ASQoL）评估患者生活质量。结果 共纳入患者206例，中位年龄37.4岁，男性患者占75.2%（155/206），HLA-B27阳性患者占59.2%（122/206）。Kendall'相关分析结果显示，与ASQoL评分相关的因素有年龄、体质量指数（BMI）、学历、工作状况、病程、婚姻状况和HLA-B27，其中年龄与ASQoL的相关系数最大（r=0.815），其次为病程（r=0.786）。多重线性回归分析显示，影响ASQoL评分的因素为年龄、HLA-B27、工作状况、学历和婚姻状况，其中影响最大的因素为年龄（β=0.654），其次为HLA-B27（β=0.335）。结论 年龄、HLA-B27、工作状况、学历和婚姻状况是AS患者ASQoL评分的影响因素。在AS的长期治疗中需要积极干预，以提高患者生活质量。 |
| 关键词：脊柱炎,强直性 生活质量 因素分析,统计学 |
| Analysis of factors influencing quality of life in patients with ankylosing spondylitis Fulltext |
| WANG Mao-rong PENG Na* |
| Department of Orthopaedics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China |
| Fund Project: |
| Abstract: |
| Objective To explose the factors influencing quality of life in patients with ankylosing spondylitis（AS）. Methods The AS patients who were treated in our hospital in 2017-2019 were selected as the research objects. The fasting venous blood samples were collected to detect human leukocyte antigen B27（HLA-B27），C-reactive protein（CRP） and erythrocyte sedimentation rate（ESR）. The ankylosing spondylitis disease activity score-C-reactive protein index（ASDAS-CRP） was used to assess the patient's disease activity. The modified stoke ankylosing spondylitis spine score（mSASSS） was used for spinal lesions；the Ankylosing Spondylitis Quality of Life（ASQoL） was used to assess the patient's quality of life. Results A total of 206 patients were enrolled in the study，with the median age of 37.4 years old，75.2%（155/206） being male，and 59.2%（122/206） being HLA-B27 positive. Kendall' correlation analysis showed that ASQoL was correlated with age，body mass index，education，work status，duration of disease，marital status and HLA-B27，among which the correlation coefficient between age and ASQoL was the largest（r=0.815），followed by disease course（r=0.786）. Multiple linear regression analysis showed that age，HLA-B27，work status，education and marital status were the factors influencing ASQoL，among which the most influential factor was age（β=0.654），followed by HLA-B27（β=0.335）. Conclusion Age，HLA-B27，work status，education and marital status have a greater impact on ASQoL in AS patients. Active intervention in long-term treatment of AS is needed to improve quality of life in AS patients. |
| Keywords:Spondylitis,ankylosing Quality of life Factor analysis,statistical |
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